Fig. 2: The α-Syn mice on a high-fat diet exhibit resistance to gaining body weight.

Mean change from initial body weights of 1-month male (a), 4-month male (b), 12-month male (c), and 4-month female (d) mice, expressed ± standard error. The number of mice for each group is shown in parentheses. Statistical analysis was performed separately for the high-fat diet (P < 0.0001 for a–d) and regular diet groups, using two-way repeated measures ANOVA. For the regular diet groups, the weight difference did not reach statistical significance for the 1-month male (P = 0.2127) and 4-month female (P = 0.3355) groups, whereas the differences were statistically significant for the 4- and 12-month male groups (P < 0.0001).