Fig. 9: Body composition measured by organ weight.

Fat composition was measured by weighing, subcutaneous inguinal white adipose tissue (iWAT), gonadal white adipose tissue (gWAT), and brown adipose tissue (BAT) (a–d). The weights of organs other than liver were unaffected (e–h). The number of mice for each group is shown in parentheses. Statistical analysis for iWAT, gWAT, and BAT were performed using two-way ANOVA with Tukey’s multiple comparison test. Statistical analysis for organs was performed separately for the high-fat diet and regular diet sub-groups using unpaired t-tests. *P < 0.0444; **P < 0.0041; ***P < 0.0009, and ****P < 0.0001.