Fig. 3: Parkinson’s disease (PD) risk stratified by severity status of GBA1 carrier and polygenic risk score (PRS) categories. | npj Parkinson's Disease

Fig. 3: Parkinson’s disease (PD) risk stratified by severity status of GBA1 carrier and polygenic risk score (PRS) categories.

From: Penetrance of Parkinson’s disease in GBA1 carriers depends on variant severity and polygenic background

Fig. 3

Odds ratio (OR) for PD were estimated using logistic models, while conditioning on the sex, age at assessment and the first four ancestry principal components in both UK Biobank (A) and the Luxembourg Parkinson’s Study (B). Non-carriers with intermediate PRS served as the reference group.

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