Table 1 Characteristics of the UK Biobank cohort and the Luxembourg Parkinson’s Study

From: Penetrance of Parkinson’s disease in GBA1 carriers depends on variant severity and polygenic background

Cohort

UK Biobank

Luxembourg Parkinson's study

Diagnostic

Cases

Controls

Cases

Controls

Participants, n

1636

183,589

653

767

Male, n (%)

1009 (61.7)

82,276 (44.8)

440 (67.4)

410 (53.5)

Female,n (%)

627 (38.3)

101,313 (55.2)

213 (32.6)

357 (46.5)

Age at Onset, mean (SD)

64.6 (8.6)

62.4 (11.5)

Age at assessment, mean (SD)

62.7 (5.3)

64.1 (8.0)

67.3 (10.7)

59.6 (7.12)

GBA1PVs carriers, n (%)

145 (8.8)

8874 (4.8)

65 (9.9)

34 (4.4)

Family history of PD,n (%)

157 (9.6)

7799 (4.2)

186 (28.5)

253 (33.0)