Table 5 Cox regression models of progression to dementia

Beta-blocker use

1.017

0.706–1.465

0.926

–

–

–

Beta-agonist use

–

–

–

1.091

0.568–2.096

0.793

Age at PD diagnosis

1.070

1.050–1.091

<0.001*

1.070

1.050–1.091

<0.001*

Years of education

0.982

0.937–1.030

0.456

0.981

0.935–1.028

0.416

PD duration at baseline

1.033

0.682–1.566

0.877

–

–

–

CIRS system score

0.918

0.831–1.013

0.089

0.927

0.839–1.024

0.137

Cardiovascular disease

1.213

0.871–1.691

0.253

1.198

0.873–1.645

0.264

Autoimmune/ Inflammatory disease

–

–

–

0.737

0.473–1.147

0.176

Diabetes

0.999

0.599–1.667

0.998

0.981

0.588–1.636

0.941

Smoking status

0.960

0.721–1.278

0.780

0.972

0.731–1.294

0.848

Baseline MMSE

0.846

0.795–0.900

<0.001*

0.836

0.784–0.891

<0.001*

Baseline MDS-UPDRS Part III score

1.020

1.008–1.031

0.001*

1.020

1.009–1.031

<0.001*

Cohort—CamPaIGN

0.638

0.411–0.992

0.046*

0.600

0.383–0.942

0.027*

Cohort—ICICLE

0.970

0.611–1.541

0.899

0.932

0.586–1.481

0.764

Cohort—PINE

1.030

0.675–1.573

0.889

0.981

0.653–1.474

0.928