Table 1 Randomized Control Trials for DBS in PD
Authors & Year | Location | Groups | n | Primary Outcome Blinded? | Primary Outcomes | Length | Results |
|---|---|---|---|---|---|---|---|
Deuschl et al.7 | Germany & Austria | active: STN DBS control: best medical | 156 total 78 active 78 control | No | PDQ-39 & UPDRS-III scores | 6 mos | DBS improved PDQ-39 by 25%, UPDRS-III scores by 40% |
Weaver et al.8 VA trial | USA | active: STN or GPi DBS control: best medical | 255 total 121 active 134 control | Yes | good quality on time (hours/day) | 6 mos | DBS improved good quality on time ( > 4.6 h/day), > 56% motor improvements |
Follett et al.9 VA trial | USA | STN vs. GPi DBS | 299 total 147 STN 152 GPi | Yes | UPDRS-III score (on stimulation, off medication) | 2 yrs | STN DBS reduced medication doses but worsened depression and visuomotor processing speed |
Williams et al. 10 PD SURG trial | UK | active: STN or GPi DBS control: best medical | 315 total 162 active 153 control | No | PDQ-39 scores | 1 yr | PDQ-39 summary index (94% improved), mobility, ADL, & bodily discomfort scores. |
Okun et al.11 St Jude trial | USA | active: STN sham: STN | 168 total 101 active 35 control | No | good quality on time (hours/day) | 3 mos | 4 h good quality on time, >40% UPDRS improvement |
Odekerken et al.12 NSTAPS study | Netherlands | STN vs. GPi DBS | 128 total 63 STN 65 GPi | Yes | weighted ALDS; composite cognitive, mood, behavioral score | 1 yr | Primary outcomes regarding disability equivalent; Secondary UPDRS motor outcomes: STN better |
Schuepbach et al.13 EARLYSTIM trial | Germany & France | active: STN DBS control: best medical | 251 total 124 active 127 control | No | PDQ-39 scores | 2 yrs | DBS improved PDQ-39 summary index, UPDRS parts II-IV, & good quality on time |
Vitek et al.14 INTREPID trial | USA | active: therapeutic STN control: subtherapeutic STN DBS | 160 total 121 active 39 control | Yes | good quality on time (hours/day) | 3 mos | UPDRS II scores (off meds), PDQ-39 summary index, & Schwab & England scores |
