Table 2 CSF and plasma αsyn species in subjects with S+ and S− CSF profiles

From: Phosphorylated α-synuclein in CSF and plasma does not reflect synucleinopathy

α-syn species

S+ 

S−

p value S

p value clinical group

CSF N-α-syn (pg/mL)

773 (214)

858 (367)

0.13

1.8 × 10−11

Plasma N-α-syn (pg/mL)

405936 (194560)

383423 (161492)

0.90

0.69

CSF C-α-syn (pg/mL)

1733 (622)

1796.42 (887)

0.54

2.1 × 10−5

Plasma C-α-syn (pg/mL)

92137 (77781)

97243.73 (75655)

0.60

0.90

CSF pS129 α-syn (pg/mL)

1.42 (0.58)

1.49 (0.56)

0.19

2.8 × 10−6

Plasma pS129 α-syn (pg/mL)

15.04 (10.80)

15.07 (8.39)

0.94

0.87

  1. Data are expressed as medians (interquartile range).
  2. C-α-syn C-terminal α-synuclein, CSF cerebrospinal fluid, N-α-syn N-terminal α-synuclein, n.s. not statistically significant, pS129 α-syn α-synuclein phosphorylated at serine 129, S+ positive CSF synSAA, S− negative CSF synSAA.
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