Fig. 1: Serum urea and urea cycle increased in PD patients, and MPTP-induced PD model mice showed significant motor dysfunction. | npj Parkinson's Disease

Fig. 1: Serum urea and urea cycle increased in PD patients, and MPTP-induced PD model mice showed significant motor dysfunction.

From: Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson’s disease

Fig. 1

A Serum urea creatinine levels in normal and PD patients. (n = 20) (B) Western Blot of Serum protein (C) Statistical plot of Western Blot of serum protein. (n = 3) (D) MPTP model construction process. (n = 5) (E) Body weight of mice at modeling. F Paralysis tremor score of mice. G Mouse grip strength test. H Mouse rotarod test. I Mouse open field test track map and heat map. J Mouse open field test data index. Data are presented as the mean ± SEM. Significant differences were established by Student’s t-test. ***p < 0.001, **p < 0.01, and *p < 0.05.

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