Fig. 2: Nigra striatum of MPTP-induced PD model mice showed obvious pathological manifestations.
From: Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson’s disease
A Gross morphology of mouse kidney and HE staining (bar = 100 μm). B Mouse kidney-to-body weight ratio, serum urea and creatinine. C Mouse substantia nigra and striatum TH immunohistochemistry. (bar = 250 μm, bar = 1 mm). D The average optical density and the number of positive cells in the substantia nigra and striatum. E HE staining of mouse substantia nigra (short bar = 250 μm, long bar = 100 μm). F Nissl staining of mouse substantia nigra (short bar=250μm, long bar = 100 μm). G HE staining of mouse striatum (short bar = 1 mm, long bar = 100 μm). H Nissl staining of mouse striatum (short bar = 1 mm, long bar = 100 μm). I Western Blot analysis of TH, A-Synuclein in the substantia nigra and striatum of mice and protein expression and relative expression statistics. (n = 3). Data are presented as the mean ± SEM. Significant differences were established by Student’s t-test. ***p < 0.001, **p < 0.01, and *p < 0.05.
