Fig. 3: Mediation effects of regional brain volume on the association between anxiety disorders and anxiolytic drugs with the incidence of Parkinson’s disease.
From: Association between anxiety disorder, anxiolytic drugs, and risk of incident Parkinson’s disease
a β1*β2 the indirect effect, β the total effect, β’ the direct effect. MEP mediation effect proportion, GAD generalised anxiety disorder, OCD obsessive-compulsive disorder, PTSD post-traumatic stress disorder, SSRIs selective serotonin reuptake inhibitors, BDZs benzodiazepines, SNRIs serotonin norepinephrine reuptake inhibitors. b Visualisation of regional brain volumes with mediation effects. L left, R right. The structural localisation of positive brain volume clusters was conducted using the Automated Anatomical Labelling of Activations in SPM with a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain (AAL), available online (https://neurovault.org/images/14257/), and the results were visualised using the Brain ViewNet system (BrainView, USA).
