Fig. 5: Inhibition of GABA release by homodimeric mGlu4 receptors at the synapse between striatal projection neurons of the indirect pathway and neurons of the external globus pallidus. | npj Parkinson's Disease

Fig. 5: Inhibition of GABA release by homodimeric mGlu4 receptors at the synapse between striatal projection neurons of the indirect pathway and neurons of the external globus pallidus.

From: Targeting metabotropic glutamate receptors for symptomatic and disease-modifying treatment in Parkinson’s disease

Fig. 5

Through this mechanism, mGlu4 receptor agonists or PAMs may improve motor symptoms in PD and restrain excitotoxic degeneration of nigral neurons (A). Inhibition of glutamate release by heterodimeric mGlu2/mGlu4 receptors in cortico-striatal fibers (B). Whether mGlu2/mGlu4 heteromers are localized in the pre-terminal region of the axon terminal or in the active zone of neurotransmitter release is unknown.

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