Fig. 4: Variance explained by schizophrenia PRS by diagnostic method compared to PGC studies.
From: Assessing the validity of a self-reported clinical diagnosis of schizophrenia
The variance explained by schizophrenia PRS in schizophrenia case/control status on the liability scale assuming a 1% population prevalence of European genetic ancestry PGC cohorts. The lines plotted on the graph represent the r2 of each diagnostic group. SZ, MDD and BP PRS are plotted as a reference. Clinical clinically-ascertained sample, UKBB UK Biobank, MDD major depressive disorder, BP bipolar disorder, SZ schizophrenia, PGC Psychiatric Genomics Consortium.
