Fig. 2: Canonical correlations and canonical loadings between cognitive performance and functional network connectivity features.
A Scatterplots of the first (left), second (center), and third (right) canonical pairs in the discovery set. Canonical correlations: rDis1 = 0.49, pDis1 = 0.001; rDis2 = 0.34, pDis2 = 0.001; rDis3 = 0.33, pDis3 = 0.001. P-values computed with 1000 permutations. B Scatterplots of the first (left), second (center), and third (right) canonical pairs in the replication set. Canonical correlations: rRep1 = 0.47, pRep1 < 0.001; rRep2 = 0.24, pRep2 < 0.001; rRep3 = 0.13, pRep3 = 0.002. C Loadings (Pearson correlation between cognitive subtests and cognitive canonical variates) for Brief Assessment of Cognition in Schizophrenia (BACS, blue) subtests and Weschler Memory Scales (WMS, red) Backward and Forward for the first (left), second (center) and third (right) canonical pairs. D Loadings (Pearson correlation between Functional Network Connectivity (FNC) and FNC canonical variates) for the 5460 FNC and the first (left), second (center), and third (right) canonical pairs. Loadings are represented in 105 × 105 symmetric matrices. The 105 multiscale intrinsic connectivity networks are grouped as follows: Visual networks (VI), cerebellar networks (CB), temporal networks (TP), subcortical networks (SC), somatomotor networks (SM), and high cognitive processing networks (HCP). E–G Brain maps in MNI152 space, where nodes are the coordinates of peak activation points of the 105 intrinsic connectivity networks and edges are 10% FNC features with the highest loadings for each FNC canonical variate (E, first; F, second; G, third). H Violin plots of participants with psychosis and controls pairwise comparisons of the first (left) and second (right) canonical pairs in the replication set. Two-tailed t-tests obtained from linear models adjusting for covariates: First functional network canonical variate, d = 0.58, t(466) = 5.28, padj < 0.0001; First cognitive canonical variate, d = 0.53, t(466) = 5.05, padj < 0.0001; Second functional network connectivity canonical variate, d = 0.07, t(466) = 0.56, padj = 0.84; Second cognitive canonical variate, d = 0.35, t(466) = 3.05, padj = 0.007. t: t-statistic, t(degrees of freedom), d: difference. * statistically significant differences between groups. EMM: Estimated Marginal Mean. P-value: Tukey method for comparing a family of 3 estimates.
