Fig. 5: Comparison of demographic and clinical characteristics (II) and childhood learning difficulties between biotypes.

A Patients from discovery set: biotype 1, N = 426; biotype 2, N = 497. B Patients from replication set: biotype 1, N = 110, N = 146. C First-degree relatives: biotype 1, N = 153; biotype 2, N = 178, control biotype, N = 95. * Non-adjusted p-value < 0.05 from Pearson’s Chi-squared test; ** False discovery rate correction for multiple testing p-value < 0.05. DSM diagnosis in first-degree relatives refers to the diagnosis of the affected family member. Statistical details are shown in Tables S2, S3 and S4. First-degree relatives with a diagnosis of a psychotic disorder were excluded from these analyses.