Table 2 Group differences in schizophrenia severity scores, cumulative drug doses, and imaging metrics after the 5-year treatment period.

PANSS positive

10.11 ± 2.92

8.50 ± 0.23

-

0.042^a

PANSS negative

9.46 ± 3.00

7.95 ± 0.02

-

0.016^a

PANSS general

27.01 ± 0.31

20.00 ± 2011

-

<0.001^a

AHRS

18.45 ± 5.33

3.10 ± 1.25

-

<0.001^a

Accumulated chlorpromazine equivalent (mg)

1817700 ± 126615

1404413 ± 90450

-

<0.001^a

Mean FA of clusters with significant group differences in FA

0.54 ± 0.02

0.67 ± 0.04

0.48 ± 0.01

<0.001^b

Mean AD of clusters with significant group differences in FA

0.88 ± 0.02 ⁽¹⁰⁻³⁾

0.92 ± 0.02 ⁽¹⁰⁻³⁾

0.86 ± 0.03 ⁽¹⁰⁻³⁾

<0.001^b

Mean RD of clusters with significant group differences in FA

0.51 ± 0.05⁽¹⁰⁻³⁾

0.59 ± 0.05⁽¹⁰⁻³⁾

0.42 ± 0.01 ⁽¹⁰⁻³⁾

<0.001^b

Mean MD of clusters with significant group differences in FA

0.63 ± 0.03 ⁽¹⁰⁻³⁾

0.72 ± 0.08 ⁽¹⁰⁻³⁾

0.50 ± 0.07 ⁽¹⁰⁻³⁾

<0.001^b