Table 5 Information for the 17 core targets.
Drug | Disease | NO. | Gene symbol | PDB ID | Protein name | Degree |
|---|---|---|---|---|---|---|
Valbenazine | TD | 1 | DRD2 | 6CM4 | Dopamine Receptor D2 | 16 |
| Â | 2 | MAOB | 6FW0 | Monoamine Oxidase B | 15 | |
| Â | 3 | DRD1 | 7JVP | Dopamine Receptor D1 | 13 | |
| Â | 4 | SLC6A3 | 8Y2D | Solute Carrier Family 6 Member 3 | 13 | |
| Â | 5 | SLC18A2 | 8JSW | Solute Carrier Family 18 Member A2 | 8 | |
| Â | 6 | DRD3 | 8IRT | Dopamine Receptor D3 | 8 | |
Deutetrabenazine | TD | 1 | MAOA | 6EZZ | Monoamine Oxidase A | 22 |
| Â | 2 | DRD2 | 6CM4 | Dopamine Receptor D2 | 20 | |
| Â | 3 | MAOB | 6FW0 | Monoamine Oxidase B | 20 | |
| Â | 4 | SLC6A3 | 8Y2D | Solute Carrier Family 6 Member 3 | 17 | |
| Â | 5 | DRD1 | 7JVP | Dopamine Receptor D1 | 16 | |
| Â | 6 | SLC18A2 | 8JSW | Solute Carrier Family 18 Member A2 | 12 | |
Vitamin E | TD | 1 | AKT1 | 8R5K | AKT Serine/Threonine Kinase 1 | 37 |
| Â | 2 | INS | 4AJX | Insulin | 35 | |
| Â | 3 | BDNF | 5UGG | Brain Derived Neurotrophic Factor | 27 | |
| Â | 4 | NOS3 | 6PP1 | Nitric Oxide Synthase 3 | 17 | |
| Â | Â | 5 | TLR4 | 5UCA | Toll Like Receptor 4 | 15 |
