Fig. 1: Study design.
From: Association between antidiabetic drug targets and psychiatric disorders
A Workflow for identifying antidiabetic drug target genes. B Diagram of the MR analysis. C Colocalization analyses confirming significant MR signals. D Replication MR analyses using multiple datasets. E Functional analyses, including single-cell gene annotation, developmental trajectory mapping, phenome-wide association studies, gene set enrichment, and drug–gene interaction analyses. eQTL expression quantitative trait loci, pQTL protein abundant quantitative trait loci, GTEx genotype-tissue expression, ROSMAP Religious Orders Study and Rush Memory and Aging Project, PGC Psychiatric Genomics Consortium, MR Mendelian randomization, PP.H4 posterior probability for hypothesis 4, SCZ schizophrenia, BD bipolar disorder, eQTLGen eQTLGen Consortium, UMAP uniform manifold approximation and projection, DGIdb drug-gene interaction database, GO gene ontology, KEGG Kyoto Encyclopedia of Genes and Genomes.
