Table 4 Multivariate Cox regression analysis for overall and non-violent mortality.

Baseline predictors	Type	Overall mortality			Non-violent deaths
Baseline predictors	Type	HR	95% CI	P	HR	95% CI	P
Sex	Male	1.00 (Reference)			1.00 (Reference)
	Female	0.83	0.57–1.20	0.321	0.96	0.60–1.53	0.860
DUP	<1 year	1.00 (Reference)			1.00 (Reference)
	1–2 years	0.90	0.60–1.36	0.620	0.60	0.35–1.02	0.058
	2–3 years	0.89	0.36–2.21	0.799	0.90	0.30–2.66	0.843
	>3 years	1.00	0.55–1.83	0.989	0.92	0.45–1.88	0.820
Age	<30 years	1.00 (Reference)			1.00 (Reference)
	30–39 years	1.46	0.32–6.65	0.621	1.30	0.28–6.11	0.736
	40–49 years	3.01	0.70–12.93	0.137	2.07	0.46–9.26	0.340
	50–59 years	4.86	1.14–20.66	0.032	3.98	0.92–17.28	0.065
	60–69 years	9.57	2.17–42.28	0.003	5.96	1.27–27.98	0.024
	70–75 years	19.58	3.89–98.48	<0.001	20.05	3.81–105.62	<0.001
	>76 years	21.51	3.64–127.05	0.001	24.87	4.06–152.25	0.001
Age of onset	Typical onset	1.00 (Reference)			1.00 (Reference)
	Early onset	0.62	0.14–2.65	0.514	1.02	0.23–4.53	0.977
	Late onset	0.72	0.35–1.49	0.379	0.88	0.37–2.09	0.769
Antipsychotic treatment	FGAs	1.00 (Reference)			1.00 (Reference)
	SGAs	0.42	0.27–0.66	<0.001	0.43	0.25–0.72	0.001
	Association of FGAs and SGAs	0.23	0.03–1.72	0.153	0.0	0–6.81e + 214	0.959
	Clozapine treatment group	1.05	0.59–1.88	0.862	1.16	0.60–2.24	0.658
Long-Acting Injectables	Non-LAI	1.00 (Reference)			1.00 (Reference)
	SG LAIs	0.33	0.08–1.40	0.132	0.24	0.03–1.82	0.169
	FG LAIs	0.85	0.47–1.51	0.577	0.55	0.25–1.23	0.144
Hospital readmission	High frequency	1.00 (Reference)			1.00 (Reference)
	Moderate frequency	0.14	0.04–0.43	0.001	0.23	0.05–1.12	0.069
	Low frequency	0.05	0.01–0.19	<0.001	0.12	0.02–0.66	0.015

Typical onset = 18–40 years; Early onset < 18 years; Late onset > 40 years²³
Hospital readmission – High frequency – more than one hospitalization per year; Moderate frequency – approximately one hospitalization per year; Low frequency – no more than one hospitalization every two years
HR Hazard Ratio, 95% CI 95% Confidence Interval, Pp-value, DUP Duration of Untreated Psychosis, FGAs First-Generation Antipsychotics, SGAs Second-Generation Antipsychotics, LAIs Long-Acting Injectables, FG LAIs First-Generation Long-Acting Injectables, SG LAIs Second-Generation Long-Acting Injectables, N/A Not Applicable, ∞ Infinity.

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