Fig. 6: Schematic representation of selected impacts of MGO exposure in SH-SY5Y cells. | npj Science of Food

Fig. 6: Schematic representation of selected impacts of MGO exposure in SH-SY5Y cells.

From: An integrated proteomics and metabolomics analysis of methylglyoxal-induced neurotoxicity in a human neuroblastoma cell line

Fig. 6

a Effects on energy metabolism, showing disruptions in glycolysis, TCA cycle, and oxidative phosphorylation. b Effects on Nrf2/GSH axis, depicting activation of the Nrf2 pathway and upregulation of GSH levels. c Effects on amino acid catabolism, detailing disruptions in arginine biosynthesis and related impacts on the urea cycle induced by MGO. Red arrows indicate upregulation, blue arrows indicate downregulation, based on integrated omics analyses. Figure created with BioRender.com.

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