Fig. 4: Antifolate drug targets.
From: Biological, dietetic and pharmacological properties of vitamin B9
Summarized pathways of folate metabolism. The blue area marks de novo folate synthesis exclusive to bacteria and some protozoa. Principal enzymes targeted by antifolate drugs are highlighted in red. Protozoa express a bifunctional enzyme with dihydrofolate reductase and thymidylate synthase activity on a single protein. GTP guanosine triphosphate, DHPPP 6-hydroxymethyl-7,8-dihydropterin pyrophosphate, DHP 7,8-dihydropteroate, DHF dihydrofolate, THF tetrahydrofolate, CH3-THF 5-methyl-THF, CH2=THF 5,10-methylene-THF, DHPS dihydropteroate synthase, DHFS dihydrofolate synthase, DHFR dihydrofolate reductase, TYMS thymidylate synthase.
