Table 3 Antifolate drugs
From: Biological, dietetic and pharmacological properties of vitamin B9
Drugs | Target enzyme | Indications |
|---|---|---|
Methotrexate, pralatrexate, (piritrexim), (talotrexin) | Human dihydrofolate reductase | Cancer autoimmune diseases |
Raltitrexed, plevitrexed, (nolatrexed) | Human dihydrofolate reductase thymidylate synthase GARFT | Cancer |
Pemetrexed | Human dihydrofolate reductase thymidylate synthase GARFT AICAR formyl transferase | Cancer |
Pyrimethamine, proguanil | Protozoal dihydrofolate reductase | Malaria, toxoplasmosis |
Trimethoprim, brodimoprim, (iclaprim) | Bacterial dihydrofolate reductase | Antibiotic |
Sulfonamides, dapsone | Bacterial DHFR | Antibiotic |
