Table 2 List of the significant (p < 0.05) differentially expressed genes (DEGs) associated with AS, and their respective fold changes identified among pairwise comparisons of control mice (CK), high-fat diet (M) mice subjected to high dose of plasmalogens (PLH), low dose of plasmalogens (PLL), and atorvastatin (ATV) supplementation

 Acox2^d

Acyl-Coenzyme A oxidase 2

4.85

0.98

0.49

0.52

 Alox12b

Arachidonate 12-lipoxygenase 12 R type

202.62

0.80

0.03

0.01

 Alox12e^c

Arachidonate lipoxygenase, epidermal

11.55

0.28

0.18

0.53

 Cbr2

Carbonyl reductase 2

20.24

0.79

0.19

0.41

 Cyp4a12b^c,d

Cytochrome P450, family 4, subfamily a, polypeptide 12B

4.98

0.75

0.43

0.32

 Hpgds

Hematopoietic prostaglandin D synthase

0.80

1.13

1.45

3.63

 Pla2g4f ^c

Phospholipase A₂, group IID

32.27

1.15

0.01

0.41

 Ptgs2

Prostaglandin-endoperoxide synthase 2

1.39

0.91

0.26

0.26

 Calml3^c

Calmodulin-like 3

10.93

0.97

0.10

0.12

 Calm4^c

Calmodulin 4

239.53

0.48

0.00

0.12

 Ccl3

Chemokine (C-C motif) ligand 3

2.77

1.17

0.05

0.07

 Cd14

CD14 antigen

4.89

0.68

0.25

0.39

 Cyp2j12

Cytochrome P450, family 2, subfamily j, polypeptide 12

20.57

0.00

0.39

0.00

 Fos^b,c

FBJ osteosarcoma oncogene

2.95

0.21

0.06

0.07

 Hsp90aa1⁵

Heat shock protein 90, alpha, class A 1

3.04

0.80

0.52

0.71

 Il1α^b

Interleukin 1 alpha

4.94

1.04

0.13

1.34

 Il1r2^c

Interleukin 1 receptor, type II

17.42

1.23

0.12

0.30

 Jun^b

Jun proto-oncogene

1.38

0.69

0.46

0.43

 Mapk13^b,c

Mitogen-activated protein kinase 13

3.63

0.80

0.08

0.17

 Mapk15

Mitogen-activated protein kinase 15

80.21

0.92

0.11

0.46

 Pou2f3

POU domain, class 2, transcription factor 3

7.07

0.64

0.27

0.27

 Sdc1

Syndecan 1

4.34

1.00

0.29

0.53

 Tnf^b,c

Tumor necrosis factor

2.07

1.07

0.17

0.24

 Cacng1

Calcium channel, voltage-dependent, gamma 1

104.53

0.17

0.26

0.42

 Creb3l3^c

cAMP responsive element binding protein 3-like 3

1.98

0.47

0.00

0.14

 Efna3

Ephrin A3

5.09

0.94

0.05

0.13

 Fgf6

Fibroblast growth factor 6

54.49

0.10

1.54

1.80

 Npy

Neuropeptide Y

34.51

0.06

0.06

0.00

 Npy5r

Neuropeptide Y receptor Y5

2.80

0.00

0.00

0.00

 Ntf5

Neurotrophin 5

29.08

0.67

0.36

0.96

 Ntrk1^c

Neurotrophic tyrosine kinase, receptor, type 1

59.11

0.03

0.87

0.34

 Casp1

Caspase 1

2.35

0.77

0.45

1.37

 Casp4

Caspase 4

2.00

0.77

0.55

1.24

 Casr

Calcium-sensing receptor

26.17

0.08

0.62

0.44

 Ccl20

Chemokine (C-C motif) ligand 20

17.75

0.41

0.18

0.20

 Cxcl5

Chemokine (C-X-C motif) ligand 5

21.28

1.06

0.24

0.35

 Il1f8

Interleukin 1 family, member 8

26.44

1.07

0.00

0.10

 Il18r1

Interleukin 18 receptor 1

6.49

1.31

0.37

1.73

 Il1rl2

Interleukin 1 receptor-like 2

4.51

1.00

0.26

0.44

 Lif

Leukemia inhibitory factor

7.30

0.43

0.14

0.28

 Panx1

Pannexin 1

3.96

0.51

0.61

1.74

 Apoa1

Apolipoprotein A-I

0.02

3.30

2.32

10.33

 Apoe

Apolipoprotein E

0.03

0.93

1.41

1.17

 Cel

Carboxyl ester lipase

1.73

0.00

0.00

0.00

 Clps

Colipase, pancreatic

1.34

0.47

0.15

0.11

 Nceh1

Neutral cholesterol ester hydrolase 1

0.83

1.22

3.34

2.66

 Pnlip

Pancreatic lipase

1.25

0.00

0.00

0.00

 Pnliprp1

Pancreatic lipase related protein 1

2.61

0.34

0.00

0.22

 Slc27a5

Solute carrier family 27 (fatty acid transporter), member 5

0.18

2.49

2.63

3.06

 Aldh3a1

Aldehyde dehydrogenase 3A1

109.20

1.00

0.09

0.13

 Edn3

Endothelin 3

14.78

0.13

0.63

0.22

 Ffar1

Free fatty acid receptor 1

0.17

8.53

12.05

420.48

 Nos1

Nitric oxide synthase 1, neuronal

44.17

0.17

0.33

0.94

 Prkag3

Protein kinase, AMP-activated, gamma 3

22.54

0.27

0.34

0.45

 Sult2b1

Sulfotransferase family, cytosolic 2B1

10.13

0.61

0.07

0.14