Table 3 Mediation by absenteeism at age 14–16 of associations of health conditions with educational attainment at 16.

Exposure	Age	Pathway	Beta^a	LCI	UCI	p	% mediated
SDQ-HI score^b for ADHD	10	Direct	−23.77	−26.13	−21.41	<0.001	7.05
		Indirect	−1.80	−2.84	−0.77	<0.001
		Total	−25.58	−28.02	−23.13	<0.001
MFQ score^c for depressive symptoms	10	Direct	−14.54	−17.22	−11.87	<0.001	11.26
		Indirect	−1.84	−3.02	−0.67	0.002
		Total	−16.39	−19.18	−13.59	<0.001
SCDC score^d for autistic social traits	10	Direct	−18.01	−20.62	−15.39	<0.001	13.13
		Indirect	−2.72	−3.93	−1.51	<0.001
		Total	−20.73	−23.36	−18.10	<0.001
Migraines at 10	10	Direct	−1.84	−10.95	7.26	0.69	71.97
		Indirect	−4.73	−8.28	−1.19	0.01
		Total	−6.58	−16.11	2.96	0.18
Asthma in past 12 months	10	Direct	5.87	−0.30	12.05	0.06	−184.97
		Indirect	−3.81	−6.34	−1.28	0.003
		Total	2.06	−4.39	8.51	0.53
BMI z-score^f	10	Direct	−1.38	−3.44	0.67	0.19	39.87
		Indirect	−0.92	−1.89	0.05	0.06
		Total	−2.30	−4.42	−0.18	0.03
SDQ-HI score^b for ADHD	13	Direct	−26.35	−28.71	−23.98	<0.001	8.37
		Indirect	−2.41	−3.50	−1.31	<0.001
		Total	−28.75	−31.14	−26.37	<0.001
MFQ score^c for depressive symptoms	13	Direct	−4.60	−7.28	−1.92	<0.001	32.63
		Indirect	−2.23	−3.43	−1.03	<0.001
		Total	−6.83	−9.61	−4.05	<0.001
SCDC score^d for autistic social traits	13	Direct	−21.73	−24.50	−18.96	<0.001	13.87
		Indirect	−3.50	−4.80	−2.20	<0.001
		Total	−25.23	−28.00	−22.47	<0.001
Asthma in past 12 months	13	Direct	2.07	−4.28	8.41	0.52	262.50
		Indirect	−3.34	−5.93	−0.75	0.01
		Total	−1.27	−7.87	5.32	0.71
BMI z-score^f	13	Direct	−2.71	−4.78	−0.65	0.01	32.08
		Indirect	−1.28	−2.24	−0.32	0.01
		Total	−3.99	−6.12	−1.87	<0.001

^aFor binary exposures, coefficients represent change associated with presence vs. absence of the health condition. For continuous exposures, coefficients represent change associated with a 1 standard-deviation increase from sample mean.
^bSDQ-HI: Strengths and Difficulties Questionnaire hyperactivity subscale.
^cMFQ: Mood and Feelings Questionnaire.
^dSCDC: Social Communication Disorders Checklist.
^fBased on 1990 UK Growth Reference, values represent SD difference from age-specific and gender-specific reference mean.

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