Fig. 7: Pre-treatment biomarker ranking.
From: Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model
Top 15 single predictive biomarkers ranked based on response probability (a) and responder inclusion score (RIS) (b). c, d Comparison of response probability and RIS of the best single biomarker and biomarker combinations. e, f Distribution of response probability and RIS for all the biomarkers and their combinations tested. Response probability is calculated as the fraction of responders among VPs included in the subset. RIS is defined as the difference between the fraction of responders selected among responders in the entire patient cohort and the fraction of non-responders selected among non-responders in the whole cohort. Statistical significance is calculated using Wilcoxon test (ns/NS: p > 0.05; *: p ≤ 0.05; **: p ≤ 0.01; ****: p ≤ 0.0001). Box represents the interquartile range (IQR), line within the box indicates the median value of the data, whiskers extend to the smallest and largest values within 1.5 * IQR, outliers are the individual points that fall outside the whiskers. Patients with CR/PR were considered as responders. IFNg interferon-γ, Ag antigen, APC antigen-presenting cell, Th helper T cell.
