Fig. 1: Simulation of cell cycle progression, survival and proliferation.

Markov models used in simulating cell attachment and proliferation and cell population produced through them. a Schema of states and transitions used to simulate phase changes and cell replication. b Growth of a simulated population with average duplication time of 24 h in which cells are duplicated according to the Markov chain based cell cycle model; the different lines report the number of cells in the different cycle phases over time. c Cell volume plotted as a function of cell age. Each line corresponds to one of the simulated cells in the population. The thicker curve represents the average volume. d Cell volume values in different cycle phases; circles correspond to individual cells at a given time. e The succession of states used to model attachment and spreading to the plate substratum. Dashed arrows indicate phase changes in the cell cycle which produce forced changes in attachment state. f Cell surface plotted, separately for each cell, as a function of cell age.