Fig. 7: SimulCell web application.
a The setup page is used to define a multi-experiment run using the available plates, cells and events and gives access to all parameters needed to run a simulation through dialog sections customised for plate, cell and event. b The result page gives access to the simulation results using customised tables and plots and showing videos to display cell behaviour. c Simulated “symbolic” representations of cell morphology compared to phase contrast images of experimental NIH3T3 cells under similar conditions: cells are visualised as oval shapes, whose size and elongation depend on cell features as well as simulated volume and degree of spreading; as for their experimental counterpart, border colour is dimmer in fully spread cells and becomes thicker and clearer when cells de-spread during nuclear duplication and division or apoptosis.
