Fig. 8: Experiment examples performed within SimulCell.

a Number of simulated NIH3T3-like cells while responding to an antibiotic added to the medium at time 6 h and followed for 8 days. b Phase-contrast like images of the same population on days 0, 1, 3 and 6. c Production of antibiotic-resistant clones by DNA transfection. After transfection with an antibiotic resistance gene at time 0, the number of total simulated NIH3T3-like cells (blue line), non-transfected (green line) and transfected cells (yellow line) is reported over time while cells respond to an antibiotic added to the medium at time 6 h. d Phase contrast like images of the same population on days 1, 4, 6 and 8. e–g Production of foci by overgrowth after transformation by exogenous DNA. The total number of cells (blue line) and the number of cells in S (green line) and G₀ (yellow line) phase after transfection with constitutively activated Ras gene at time 12 h and serum step down to 1% FBS ate time 24 h is reported for non transfected (e) and transfected cells (f). g Phase contrast like images of the same population on days 2, 6, 8 and 10. h Number of dead (blue line) and infected (green line) simulated VeroE6 cells after infection with a lytic virus (9 h replication time). i Phase contrast like images of the same population on days 2, 3 and 4.