Fig. 1: Computational and molecular perspectives on ACE2 in diabetic retinopathy.
From: Systems biology and microbiome innovations for personalized diabetic retinopathy management
(top) Overview of the application of computational methods on diabetic retinopathy at different scales, with a focus on ACE2; (bottom) the renin-angiotensin system is upregulated during inflammatory states, resulting in increased synthesis of Ang2. This heightened production of Ang2 can happen both systemically and locally within organs, inducing vessel vasoconstriction. ACE2 can degrade Ang2 (ACE2, angiotensin-converting enzyme 2; Ang2, angiotensin II; RAS, renin–angiotensin system).
