Fig. 4: Dynamics of the CCL4–CCR5/CCL4–CCR8 binding and optic glioma growth in response to CCL4 fluctuation. | npj Systems Biology and Applications

Fig. 4: Dynamics of the CCL4–CCR5/CCL4–CCR8 binding and optic glioma growth in response to CCL4 fluctuation.

From: Asthma-mediated control of optic glioma growth via T cell-microglia interactions: A mathematical model

Fig. 4

Time courses of concentrations of CCR5/CCL4–CCR5 complex (A) and CCR8/CCL4–CCR8 complex (B) in response to high ([L4] = 50 nM) and low ([L4] = 0.1 nM) CCL4 stimuli. C Binding response to CCL4 in the core control system. Time courses of CCL4-CCR5 (red solid, E) and CCL4-CCR8 (blue dashed, E) binding activity in response to a fluctuating CCL4 input (D): \([{L}_{4}](t)=10\cos (\pi t/240)+10\). F Time courses of the NFκB (red solid) and CCL5 (blue dashed) under L4(t) in (D). G Time courses of the cancer cell density under L4(t) in (D).

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