Fig. 7: Role of decorin in dynamics of CCL4–CCR5/CCL4–CCR8 receptor binding.

Time courses of levels of CCR8/DCN–CCR8 complex (A) and CCR8/CCL4–CCR8 complex (B) in response to high (D = 200 nM) and low (D = 2 nM) decorin stimuli. Initial condition: [R₂](0) = 50, \([\overline{{L}_{4}\cdot {R}_{1}}](0)=0\), \([\overline{{L}_{4}\cdot {R}_{2}}](0)=0\), \([\overline{D\cdot {R}_{2}}](0)=0\). Dynamics of the core control (\([\overline{{L}_{4}\cdot {R}_{2}}]\), \([\overline{D\cdot {R}_{2}}]\)) system (18)–(22) in the phase plane in response to low ([D] = 2 nM in (C)) and high ([D] = 200 nM in (D)) levels of the decorin, together with a schematic of anti-tumorigenic (\([\bar{D\cdot {R}_{2}}] > t{h}_{{\rm{D}}}\), \([\bar{{L}_{4}\cdot {R}_{2}}] < t{h}_{{\rm{L}}}\)) and tumorigenic (\([\bar{D\cdot {R}_{2}}] < t{h}_{{\rm{D}}}\), \([\bar{{L}_{4}\cdot {R}_{2}}] > t{h}_{{\rm{L}}}\)) regions in the DCN–CCR8/CCL4–CCR8 plane, respectively. Steady states marked with circles. E Steady states of [CCL5] in response to various decorin levels. F Binding response to decorin in the core control system. *th_D = 23, th_L = 14.