Fig. 2: mRNA-LNP vaccine induces strong genotype-specific responses. | npj Vaccines

Fig. 2: mRNA-LNP vaccine induces strong genotype-specific responses.

From: Bivalent norovirus mRNA vaccine elicits cellular and humoral responses protecting human enteroids from GII.4 infection

Fig. 2

Balb/c mice (n = 10 per group) were immunized on days 0 and 28 with 10 μg of mRNA-LNP vaccine encoding Norwalk1968/GI.1 or CapeTown2012/GII.4 VP1, or empty LNP as control at an equivalent dose. A nAb response titers to three genogroup I strains (GI.1, GI.3, and GI.5) and (B) against four genogroup II strains (GII.3, GII.4 Sydney 2012, GII.4 New Orleans 2009, and GII.4 Farmington Hills 2002) at day 56 post prime in a surrogate neutralization assay. The nAb titer is presented as 50% inhibitory dilution (ID50) values (Mean ± SD), n = 10 per group (5 male and 5 female). Only the cross-reactivity nAb titer values of GII.4 variants were compared, ∗p < 0.05, (2012 vs 2009 p = <0.0001, 2012 vs 2002 p = <0.0001) one way-ANOVA, Tukey’s post hoc tests.

Back to article page