Table 1 Neutralizing antibody titers in pre-challenge sera analyzed in a cytopathic effect (CPE)-based assay with authentic virus or an assay with pseudotyped virus

From: An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

  

Neut. titer (Authentic virus; CPE-based)

Neut. titer (pseudotyped virus)

Group

Animal ID

ch/Ghana (2.3.4.4b)

India/S4571 (2.3.2.1a)

ch/Ghana (2.3.4.4b)

Mock-vac.

#1

<20

<20

<40

#2

<20

<20

<40

#3

<20

<20

<40

#4

<20

<20

<40

#5

<20

<20

<40

1 μg

#6

<20

<20

40

#7

<20

<20

<40

#8

<20

<20

<40

#9

<20

<20

<40

#10

<20

<20

<40

10 μg

#11

<20

<20

40

#12

<20

<20

320

#13

<20

<20

320

#14

<20

<20

80

#15

<20

<20

80

  1. In the CPE-based neutralization assay, virus neutralization titers were determined as the reciprocal of the highest serum dilution that completely prevented CPE. The detection limits in the assay using authentic virus and pseudotyped virus are 20 and 40, respectively.
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