Fig. 1: H3N8 induces bnAbs to human influenza strains.
From: Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
Sera from vaccinated horses were heat inactivated and RDE treated. A HAI titers were assessed across multiple strains of influenza (n = 15). Line represents a protective reciprocal titer of 40. We do not show baseline pre-vaccination titers here since the horses are a mixed age population. B However, in a limited number of foals that we vaccinated for the first time, we did not find antibodies to any influenza antigen prior to vaccination and found equivalent HAI titers as their peers after vaccination (n = 7, as finding vaccine-free horses is difficult). p < 0.001 against unvaccinated foal sera. Mice received two doses of C H3N8 or D H3N2(A/Texas/50/12) in alum, and HAI serum titers were tested across many strains of influenza. Line indicates a minimum protective reciprocal titer of 40.Similar influenza strains were at least p < 0.001 between H3N8 and H3N2 vaccinees (n = 5 for two reps).
