Fig. 5: H3N8 protects from heterosubtypic challenge.
From: Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen
A Again, we vaccinated mice with either H3N8 whole virus, rHA from H3N8, sham, or our mix of H1/H3 Cali viruses. We assessed the collected lungs after 5 DP. and stained them with hematoxylin and eosin. (n = 5 with two reps, but representative photos are shown. Shown are A sham control, B H1/H3 Cali, C equine rHA, and D H3N8 LAIV. E Viral lung burdens were determined in 1 mg of the upper right lobe after 6 DPIs from the same mice as (A) by TCID50 assay. 20× magnification was used. The inset for 5C is also 20× magnification but the image size was reduced to show more of the lung histology.
