Fig. 5: Results of EG.5.1 variant challenge in BALB/c mice after immunization.
From: mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
a Schematic of BALB/c mouse viral infection. b Changes in the body weight of the mice after infection. c Viral RNA load in the lungs on day 5 postinfection. d Pathological scoring of the lung tissue. e Histopathological sections demonstrating lung tissue damage. f Viral RNA load detected in nasopharyngeal swabs within five days postinfection. g Viral RNA load detected in throat swabs within five days postinfection. The data are expressed as the means ± SEMs. Statistical analysis was conducted via one-way ANOVA and Tukey’s multiple comparison test. The significance of differences between the experimental group and the unimmunized control group is indicated by asterisks, and the significance of no marker indicates no significance. *P < 0.05, **P < 0.01, ***P < 0.005.
