Fig. 6: Results of EG.5.1 variant challenge in K18-hACE2 mice after immunization.
From: mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice
a Schematic of K18-hACE2 mouse viral infection. b Changes in the body weights of the mice after infection. c Survival curve within five days postinfection. d Viral RNA load in the lungs on day 5 postinfection. e Pathological scoring of lung tissue. f Histopathological sections demonstrating lung tissue damage (Placebo: n = 5, BSCoV 05, BSCoV06 and BA.1: n = 4). g Immunofluorescence of lung tissue in K18-hACE2 mice. The data are expressed as the means ± SEMs. Statistical analysis was conducted via one-way ANOVA and Tukey’s multiple comparison test. The significance of differences between the experimental group and the unimmunized control group is indicated by asterisks, and the significance of no marker indicates no significance. *P < 0.05, **P < 0.01, ***P < 0.005.
