Fig. 2: Delivery of circRNA vaccines.
From: Recent advances and perspectives on the development of circular RNA cancer vaccines
a CircRNAs are formulated in solution and then directly injected into mouse. b CircRNAs are ex vivo transfected into dendritic cells (DCs) by the nanochannel electro-injection (NEI) system. c CircRNAs are entrapped in lipid with microfluidic mixer to form lipid-based nanoparticle (LNP). Virus-like particle (VLP) (d) and adeno-associated virus (AAV) (e) can be engineered to encapsulate and deliver circRNAs. The icons of tube, dendritic cell, lipid, virus, mouse, and syringe were freely sourced from https://bioicons.com/.
