Table 1 Clinical trials of circRNA-related therapeuticsa
From: Recent advances and perspectives on the development of circular RNA cancer vaccines
Study ID | Type of cancer | CircRNA targets | Intervention/treatment | Study overview | Location | Study status |
|---|---|---|---|---|---|---|
NCT05771337 | Breast cancer | hsa_circ_0001785 (Circ-ELP3), hsa_circ_100219 (Circ-FAF1) | Diagnostic test: serum | To investigate the diagnostic value of Circ-ELP3 and Circ-FAF1 in serum samples of breast cancer patients compared to serum chemerin levels and classical tumor markers (CEA, CA15-3), and to elucidate the difference of their expression levels between metastatic and non-metastatic cases. | Egypt | Not yet recruiting |
NCT05934045 | ALK-positive anaplastic large-cell lymphoma | Undefined circRNAs | Prognostic test: plasma | To determine whether circRNAs can be used as circulating prognostic and/or predictive biomarkers of ALK + ALCL resistance to treatment and whether they can be exploited as therapeutic targets. | France | Not yet recruiting |
NCT04584996 | Pancreatic ductal adenocarcinoma (PDAC) | Undefined circRNAs | Diagnostic, prognostic and predictive tests: plasma | To evaluate candidate circRNA expression in plasma samples as diagnostic, prognostic and predictive biomarkers in PDAC, compared to CA19-9. | United Kingdom | Unknown |
NCT06042842 | Hepatocellular carcinoma (HCC) | hsa_circ_0004001 | Diagnostic test: plasma sample | To evaluate the clinical utility of plasma hsa_circ_0004001 as a diagnostic biomarker for HCC patients compared to routine marker (AFP) and to differentiate between malignant and nonmalignant hepatic disorders, to explore the relation of hsa_circ_0004001 to HCC staging. | Egypt | Not yet recruiting |
ChiCTR2300078812 | Papillary thyroid carcinoma (PTC) | Undefined circRNAs | Diagnostic test: plasma sample | To explore novel circRNAs as potential molecular markers of PTC by sequencing of PTC tissues and adjacent tissues. | China | Recruiting |
ChiCTR2300069863 | Cholangiocarcinoma (CCA) | Undefined circRNAs | Diagnostic and prognostic tests: plasma sample | To identify an exosomal circRNA signature in the diagnosis and prognosis of CCA. | China | Recruiting |
ChiCTR2000035608 | Colorectal cancer (CRC) | Undefined circRNAs | Diagnostic test: plasma sample | To establish and evaluate a standardized detection system including an extracellular vesicle (EV) nucleic acid combination (microRNA, long non-coding RNA, circRNA) using digital PCR in a series of clinical practices for CRC patients, and to compare the diagnostic efficacy of the system with colonoscopy, tissue biopsy and traditional serological markers for CRC. | China | Not yet recruiting |
ChiCTR1900024188 | Prostate cancer | Undefined circRNAs | Diagnostic test: urine sample | To explore the expression of circRNA in urinary exosomes and its clinical application for early diagnosis for prostate cancer, and to establish a relevant diagnostic model. | China | Recruiting |
ChiCTR1800019529 | Prostate cancer | Undefined circRNAs | Prognostic test: plasma sample | To evaluate the expression level of plasma circRNAs, and to establish a prognostic model of plasma circRNAs for castration-resistant prostate cancer. | China | Recruiting |
ChiCTR1800018038 | Pancreatic cancer | Undefined circRNAs | Diagnostic test: serum sample | To discover the serum exosome-derived circRNA as a novel biomarker, which supply a molecular phenotype to guide the operative decision and precise therapy for broadline resectable pancreatic cancer. | China | Not yet recruiting |
