Fig. 2: Evolutionary dynamics of H9N2 AIV in naïve and vaccinated passage lines. | npj Vaccines

Fig. 2: Evolutionary dynamics of H9N2 AIV in naïve and vaccinated passage lines.

From: Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens

Fig. 2

A Time course of H9N2 virus transmission through naïve and vaccinated passage chains. The schematic diagram was created using Adobe Illustrator and Canva (www.canva.com). B Serial intervals of viral transmission between chickens in the naïve and vaccinated passage chains, which refers to the number of days required for an uninfected animal to become infected after cohabitation with an infected animal. C Growth rate of viral replication in chickens at each passage in the naïve and vaccinated passage chains. D Nucleotide positions and absolute frequencies of mutations. E Numbers of nonsynonymous mutations at different passages. Statistical significance was assessed with two-way ANOVA (*P < 0.05; **P < 0.01).

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