Fig. 5: Effect of baseline anti-PfCSP IgG levels on post-vaccination anti-PfCSP IgG levels adjusted by exposure and age in both sites. | npj Vaccines

Fig. 5: Effect of baseline anti-PfCSP IgG levels on post-vaccination anti-PfCSP IgG levels adjusted by exposure and age in both sites.

From: Role of malaria exposure and off-target responses on RTS,S/AS02A vaccine immunogenicity and protection in Mozambican children

Fig. 5

Three multiple linear regression models are presented, each using one baseline anti-PfCSP IgG measurement (full-length [FL], NANP, or C-terminus [C-term]) as the predictor, with outcomes defined as the post-vaccination IgG levels at month (M) 3 against NANP (blue triangles) and C-term (red circles). These models were adjusted for baseline malaria exposure, measured as the sum of anti-PfEXP1 and anti-PfMSP2 IgG levels at M0, and age at first vaccination. Each forest plot displays the estimated effect sizes (multiplicative effect in the dependent variable per a 10-fold increase in the predictor) and their 95% confidence intervals.

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