Fig. 1: Immunogen design of Fluaxe.
From: Chimeric hemagglutinin and M2 mRNA vaccine for broad influenza subtype protection
A mRNA constructs of Fluaxe expressing the two chimeric HA and M2. Created in BioRender. Li (2025) https://BioRender.com/bithl81. B Monomeric structures of HA for four subtypes of IAV (H1N1, H5N1, H3N2, and H7N9) and IBV/Victoria. The disulfide bonds presented at the junction between the head and stem domains in all four IAV HA proteins are highlighted. For IBV/Victoria HA A56 and G302 residues are situated at the two equivalent structural positions instead of cysteines. C The predicted three-dimensional structure of Fluaxe chimeric sequences. The disulfide bond connecting the original head and stem fragments persists in the chimera. All structural figures were prepared using the PyMOL Molecular Graphics System, Version 3.0 (Schrödinger, LLC).
