Fig. 4: Correlations between MenACWY-specific rSBA, IgG, and IgM responses following primary and booster MenACWY-TT vaccination.

The Spearman correlation coefficient and corresponding levels of significance are shown for each pairwise combination of MenACWY-specific rSBA titers, IgG levels, and IgM levels for the whole cohort (n = 222) following primary vaccination (A). At two years (2 y) post-primary vaccination, responses were only assessed in participants who did not receive a booster vaccination at 1 y (n = 110). Additionally, correlations following booster vaccination are shown for the booster cohort (n = 104) (B), which includes only participants who received a MenACWY-TT booster vaccination at one year (1 y) post-primary vaccination. For reference, correlations observed before and after primary vaccination are also shown for the booster cohort, to allow for direct comparison between timepoints. Correction for multiple testing was performed using the Bonferroni method. The strength of the correlation is depicted by color intensity, while the significance level is indicated by the size of the dot. Spearman rho values are displayed for each pairwise correlation.