Fig. 2: mRNA-LNP vaccines elicit robust immune responses. | npj Vaccines

Fig. 2: mRNA-LNP vaccines elicit robust immune responses.

From: A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models

Fig. 2

A Schematic overview of the experimental timeline for vaccination, blood collection, challenge, and cellular immunity assessment drawn with FIGDRAW. B–F The antigen-specific antibody titers detected by ELISA. Serum samples were collected on day 14 post-primary immunization, and on days 21 (7 days post-booster) and 28 (14 days post-booster) following the booster immunization. Antigen-specific IgG titers against MntC (B), SEB (C), Hla (D), FnBPA (E), and IsdB (F) were analyzed by ELISA. G Specific IgM titers induced on day 7 post-immunization with monovalent mRNA-LNPs. H Antibody titers of IgG1 and IgG2a induced on day 28 by five monovalent mRNA-LNP vaccines. Data are represented as mean ± SD and analyzed by one-way ANOVA with Tukey’s multiple comparisons test. n = 5. ns represents no significant, p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), and p < 0.0001 (****).

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