Fig. 5: The protection efficacy of mRNA-LNP vaccine candidates evaluated in systemic infection murine model. | npj Vaccines

Fig. 5: The protection efficacy of mRNA-LNP vaccine candidates evaluated in systemic infection murine model.

From: A multivalent mRNA-LNP cocktail vaccine confers superior efficacy against Staphylococcus aureus infection in murine models

Fig. 5

A Comparative analysis of the opsonophagocytic killing activity of immune serum against Staphylococcus aureus. B Survival rate of mice over 7 days after challenge with a lethal dose of the MRSA252. C Average survival rate of three parallel experiments (n = 7). D–F Bacterial load per milliliter of blood, per gram of lung and kidney tissue 24 h after challenge with a sublethal dose of the MRSA252 (5 × 108). n = 5. Asterisks beneath each experimental group denote statistical significance versus the control group. G Hematoxylin and eosin (H&E) stained histopathological images of mice lung tissues 48 h after challenge with a lethal dose of the MRSA252. H Severity scores of lungs (n = 5) from mice 48 h post infection were shown. Data are represented as mean ± SD and analyzed by one-way ANOVA with Dunnett’s post-hoc test (C, H) and Tukey’s multiple comparisons test (D, E, F). ns represents no significant. p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), and p < 0.0001 (****).

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