Fig. 4: Serological evaluation of UNR vs. MNR mRNA-LNP vaccines in mice. | npj Vaccines

Fig. 4: Serological evaluation of UNR vs. MNR mRNA-LNP vaccines in mice.

From: Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

Fig. 4

BALB/c mice (n = 8 per group) were immunized twice intramuscularly (IM), 3 weeks apart with 1, 0.4, and 0.08 μg of different Sing16 HA mRNA-LNP formulations. Serum titers were measured by hemagglutinin inhibition assay (HAI) against homologous A/Singapore/INFIMH160019/2016 H3N2 Influenza virus strain and geometric mean titers were graphed for a Sing16 HA-OF-02, b Sing16 HA-cKK-E10 or c Sing16 HA-SM-102 LNPs.

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