Fig. 5: Serological evaluation of UNR vs. MNR mRNA-LNP vaccines in non-human primates. | npj Vaccines

Fig. 5: Serological evaluation of UNR vs. MNR mRNA-LNP vaccines in non-human primates.

From: Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

Fig. 5

Cynomolgus macaques (n = 4–6 per group) were immunized at Day 0 and Day 28 by intramuscular route with 135, 45, or 15 μg of different mRNA-LNP formulations encoding for the H3-HA protein from the A/Singapore/INFIMH-16-0019/2016 strain of influenza. Serum titers taken over the course of 1 year were measured by hemagglutinin inhibition assay (HAI) against homologous A/Singapore/INFIMH160019/2016 H3N2 Influenza virus strain and geometric mean titers were graphed for the following mRNA-LNPs: a Sing16 HA-cKK-E10 15 μg, b Sing16 HA-cKK-E10 45 μg, c Sing16 HA-cKK-E10 135 μg, d Sing16 HA-SM-102 15 μg, e Sing16 HA-SM-102 45 μg, f Sing16 HA-SM-102 135 μg.

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