Fig. 8: Top enriched canonical pathways following mRNA vaccination in non-human primates. | npj Vaccines

Fig. 8: Top enriched canonical pathways following mRNA vaccination in non-human primates.

From: Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

Fig. 8

a The heatmap depicts overrepresentation of canonical pathways enriched in whole blood of non-human primates following a 135 μg dose of mRNA-LNP (cKK-E10 and SM-102) vaccines. The color of each cell refers to the -log10 (p-value) and indicates the significance of the pathway enrichment (see color key). The color bar below the heatmap denotes the mRNA modification class (UNR: blue; MNR: red). b The heatmap depicts the top canonical pathways enriched following mRNA vaccination. The color of each cell refers to the log2 fold change of the differentially expressed genes (DEGs) composed within the pathway (see color key). Genes with a log2 fold change of more than 1 and a p-value of < 0.05 were selected for the representation. Violin plots were prepared for each of the selected pathway heatmaps to provide a visual reference of the difference in median DEG expression between treatments (quartiles as well as minima and maxima bounds are shown).

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