Table 1 Overview of studies on murine liver-arresting GAPs

From: The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy

Author

Parasite

Mother line

Murine liver-arresting GAPs that did not progress to clinical studies

Mueller et al., 200519

PbΔuis3

Pb NK65

Mueller et al., 200520

PbΔuis4

Pb NK65

Tarun et al., 200723

PyΔuis3

Py 17XNL

 

PyΔuis4

Py 17XNL

Jobe et al., 200724

PbΔuis3Δuis4

Pb NK65

Yu et al., 200829

PbΔFabl

Pb ANKA

Butler et al., 201128

PyΔFabB/F

Py 17XNL

Annoura et al., 201234

PbΔFabB/F

Pb ANKA

Murine liver-arresting GAPs that progressed to clinical studies

Van Dijk et al., 200533

PbΔp52

Pb ANKA

Labaied et al., 200731

PyΔp52Δp36

Py 17XNL

Aly et al., 201139

PyΔsap1

Py 17XNL

Kublin et al., 201741

PyΔp52Δp36Δsap1

Py 17XNL

Annoura et al., 201234

PbΔp52Δp36

Pb ANKA

Annoura et al., 201443

PbΔb9

Pb ANKA

Van Schaijk et al., 201444

PbΔb9Δslarp

Pb ANKA

Dankwa et al., 201647

PyΔmei2

Py 17XNL

Franke-Fayard et al., 202248

PbΔmei2

Pb ANKA

Goswami et al., 202454

PyΔmei2Δlinup

Py 17XNL