Extended Data Fig. 5: Quantification of PPIs and Ki67 in HCC827 cells. | Nature Biomedical Engineering

Extended Data Fig. 5: Quantification of PPIs and Ki67 in HCC827 cells.

From: Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues

Extended Data Fig. 5

a, The PPI count comparison in cytosol and nuclei is separately shown in the figure. The HCC827 cells were treated with VP at 0, 1, and 10 µM for 24 hours. b, The comparison of Ki67 density in HCC827 cells treated with and without VP. Ki67 density was calculated by dividing the Ki67 positive regions by the nuclear size. c, The comparison of Ki67 density in HCC827 cells treated with and without 100 nM Osimertinib for 12 hours. Statistical testing was performed using Mann Whitney Wilcoxon Test two-sided (***: 0.0001 < p <= 0.001, ****: p < =0.0001). Box plots and violin plots: median (horizontal line inside box), 25th and 75th percentiles (box), 25th and 75th percentiles ±1.5 times the interquartile range (whiskers).

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