Extended Data Fig. 6: PPI counts per cell and PPI density in patient tissues.
a, Quantification of PPI counts per stromal, per immune cell with immune neighbours, and PPI counts per tumour cell with tumour neighbours at the single cell level in the responder tissue. Statistical testing was performed using t-test independent samples with Bonferroni correction (***: 0.0001 < p <= 0.001, ****: p < =0.0001). b, Comparison of the density of PPI counts in lymphocyte-enriched regions between responders and non-responders. A plot with a wider y-axis range is in Supplementary Fig. 40d to show the complete individual data points. Example images of 5 PPIs expression in lymphocyte-enriched regions are shown on the right. The first column is the visualization of 5 PPIs in lymphocyte-enriched regions. The second column displays the distributions of Sox2/Oct4 PPI in red. The third column exhibits the distributions of NF-kB/p-P90RSK PPIs in green. Statistical testing was performed using t-test independent samples (***: 0.0001 < p <= 0.001, ****: p < =0.0001). Box plots and Violin plots: median (horizontal line inside box), 25th and 75th percentiles (box), 25th and 75th percentiles ±1.5 times the interquartile range (whiskers).
